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HBB Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 3
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, IHC-P, E |
|---|---|
| Primary Accession | P68871 |
| Other Accession | P04246, P02101, P02128, P06643, P06642, P02042, P02057, P02112, P02081, P11517, P02089, P02091, P02088, NP_000509.1, P68056, P02083, P02062, P02075 |
| Reactivity | Human |
| Predicted | Mouse, Rat, Sheep, Bovine, Chicken, Horse, Rabbit, Pig |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 15998 Da |
| Antigen Region | 80-107 aa |
| Gene ID | 3043 |
|---|---|
| Other Names | Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain, LVV-hemorphin-7, Spinorphin, HBB |
| Target/Specificity | This HBB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 80-107 amino acids from the C-terminal region of human HBB. |
| Dilution | WB~~1:2000 FC~~1:25 IHC-P~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HBB Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HBB |
|---|---|
| Function | Involved in oxygen transport from the lung to the various peripheral tissues. [Spinorphin]: Functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation. |
| Tissue Location | Red blood cells.. |
Provided below are standard protocols that you may find useful for product applications.
Background
The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Zhou, D., et al. Nat. Genet. 42(9):742-744(2010)
Onakoya, P.A., et al. Ear Nose Throat J 89(7):306-310(2010)
Belisario, A.R., et al. Acta Haematol. 124(3):162-170(2010)
Prakobkaew, N., et al. Acta Haematol. 124(2):115-119(2010)
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